International Journal of Clinical & Medical Images

Clinical Image

Corpus callosum (CC) is the main interhemispheric commissure. It is composed of 4 main segments from the front to the back: the rostrum, genu, body and splenium. Agenesis of the corpus callosum is frequent and mostly associated with other brain malformations while isolated agenesis of corpus callosum is rare. It can be partial or complete. Clinical symptoms may differ depending on its type and its association with malformations. It can be asymptomatic, or cause epilepsia and abnormal neurodevelopment. Imaging is the examination of choice for diagnosis. Pre-natal ultrasound and post-natal ultrasound may lead diagnosis that’s confirmed by MRI [1-3]. Complete agenesis of CC typical features is: lateral ventricles widely separated being parallel to each other, with upward bulging of the 3^rd ventricle creating a “racing car” sign. Widening of the occipital horns of the lateral ventricles named colpocephaly and appearance of frontal horns of the ventricles as a “moose head” or “Viking helmet”. Callosal fibers may be heterotopic laying besides the superomedial side of the lateral ventricles representing the bundles of Probst. The images above represent the case of an 8 years old girl, consulting for learning disabilities, with a normal neurological development and clinical examination. A brain MRI performed showed complete agenesis of the corpus callosum (Figure 1).

Keywords: Corpus; Callosum; Agenesia; Imaging; MRI