International Journal of Clinical & Medical Images

Most plasma cell neoplasms are comprised of recognisable tumour cells that can be readily identified morphologically and generally without any difficulty. However, infrequently these cells demonstrate atypical features and may possibly result in erroneous diagnosis. In such rare instances, a high index of suspicion together with extensive whole blood, serum and urine analyses, in conjunction with the additional methods of bone marrow assessment such as flow cytometry and immunohistochemistry, are generally required for definitive diagnosis, classification and prognostication.